Nadine Alvarez, Ph.D.

Research Assistant Member, Infectious Diseases
Center for Discovery and Innovation

Microbiology-Molecular Biology researcher with experience in pre-clinical research and development projects aimed towards drug discovery and vaccines. Goal oriented and focused with strong team building and supervising abilities supplemented with over 20 peer-review publications.

Research

Broad background in biotechnology, mycobacteriology and drug discovery related to Mycobacterium tuberculosis and non-tuberculous mycobacteria (NTMs). Current work is focused on the assay development and discovery of new antiviral leads to fight current viruses affecting human population worldwide, like SARS-CoV-2, as well as other viral agents that can become a potential future pandemic.

Selected Publications

1. Shurtleff VW, Layton ME, Parish CA, Perkins JJ, Schreier JD, Wang Y, Adam GC, Alvarez N, Bahmanjah S, Bahnck-Teets CM, Boyce CW, Burlein C, Cabalu TD, Campbell BT, Carroll SS, Chang W, de Lera Ruiz M, Dolgov E, Fay JF, Fox NG, Goh SL, Hartingh TJ, Hurzy DM, Kelly MJ 3rd, Klein DJ, Klingler FM, Krishnamurthy H, Kudalkar S, Mayhood TW, McKenna PM, Murray EM, Nahas D, Nawrat CC, Park S, Qian D, Roecker AJ, Sharma V, Shipe WD, Su J, Taggart RV, Truong Q, Wu Y, Zhou X, Zhuang N, Perlin DS, Olsen DB, Howe JA, McCauley JA. 2024.
   Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
   J Med Chem. 2024 Feb 16. doi: 10.1021/acs.jmedchem.3c02248.
   
   
2. Mane V, Mehta R, Alvarez N, Sharma V, Park S, Fox A, DeCarlo C, Yang X, Perlin DS, Powell RLR.
   In Vivo Antiviral Efficacy of LCTG-002, a Pooled, Purified Human Milk Secretory IgA product, Against SARS-CoV-2 in a Murine Model of COVID-19. 2024.
   Hum Vaccin Immunother. Dec 31;20(1):2303226.
   
   
3. Stampolaki M, Malwal SR, Alvarez-Cabrera N, Gao Z, Moniruzzaman M, Babii SO, Naziris N,
   Rey-Cibati A, Valladares-Delgado M, Turcu AL, Baek KH, Phan TN, Lee H, Alcaraz M, Watson S, van der Watt M, Coertzen D, Efstathiou N, Chountoulesi M, Shoen CM, Papanastasiou IP, Brea J, Cynamon MH, Birkholtz LM, Kremer L, No JH, Vázquez S, Benaim G, Demetzos C, Zgurskaya HI, Dick T, Oldfield E, Kolocouris AD. 2023.
   Synthesis and Testing of Analogs of the Tuberculosis Drug Candidate SQ109 against Bacteria and Protozoa: Identification of Lead Compounds against Mycobacterium abscessus and Malaria Parasites.
   ACS Infect Dis. Feb 10;9(2):342-364. Doi: 10.1021/acsinfecdis.2c00537.
   
   
4. Kaya F, Ernest JP, LoMauro K, Gengenbacher M, Madani A, Aragaw WW, Zimmerman MD,
   Sarathy JP, Alvarez N, Daudelin I, Wang H, Lanni F, Weiner DM, Via LE, Barry CE 3rd, Olivier
   KN, Dick T, Podell BK, Savic RM, Dartois V. 2022.
   A Rabbit Model to Study Antibiotic Penetration at the Site of Infection for Nontuberculous Mycobacterial Lung Disease: Macrolide Case Study.
   Antimicrob Agents Chemother. Mar 15;66(3): e0221221. doi: 10.1128/aac.02212-21.
   
   
5. Malwal SR, Zimmerman MD, Alvarez N, Sarathy JP, Dartois V, Nacy CA, Oldfield E. 2021.
   Structure, In Vivo Detection, and Antibacterial Activity of Metabolites of SQ109, an Anti-Infective
   Drug Candidate.
   ACS Infect Dis. Aug 13;7(8):2492-2507. doi: 10.1021/acsinfecdis.1c00259.