Sarathy Lab

Jansy P. Sarathy, Ph.D., is an Assistant Member of the Center for Discovery and Innovation HMH and an Assistant Professor at the Hackensack Meridian School of Medicine. She completed her postdoctoral research at the Public Health Research Institute, Rutgers under the guidance of veteran tuberculosis pharmacologist Dr. Véronique Dartois. Dr. Sarathy completed her graduate degree at the National University of Singapore, School of Medicine.

Selected Publications

A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum. Sarathy JP, Xie M, Jones RM, Chang A, Osiecki P, Weiner D, Tsao WS, Dougher M, Blanc L, Fotouhi N, Via LE, Barry CE 3rd, De Vlaminck I, Sherman DR, Dartois VA. mBio. 2023 Apr 5: e0059823.

Adaptation to the intracellular environment of primary human macrophages influences drug susceptibility of Mycobacterium tuberculosis. Lanni F, Wijnant GJ, Xie M, Osiecki P, Dartois V, Sarathy JP. Tuberculosis (Edinb). 2023 Mar; 139:102318.

Caseum: a Niche for Mycobacterium tuberculosis Drug-Tolerant Persisters. Sarathy JP, Dartois V. Clin Microbiol Rev. 2020 Apr 1;33(3):e00159-19.

Extreme Drug Tolerance of Mycobacterium tuberculosis in Caseum. Sarathy JP, Via LE, Weiner D, Blanc L, Boshoff H, Eugenin EA, Barry CE 3rd, Dartois VA. Antimicrob Agents Chemother. 2018 Jan 25; 62(2).

Lesion Penetration and Activity Limit the Utility of Second-Line Injectable Agents in Pulmonary Tuberculosis. Ernest JP, Sarathy J, Wang N, Kaya F, Zimmerman MD, Strydom N, Wang H, Xie M, Gengenbacher M, Via LE, Barry CE 3rd, Carter CL, Savic RM, Dartois V. Antimicrob Agents Chemother. 2021 Sep 17; 65(10).

Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations. Sarathy J, Blanc L, Alvarez N, O’Brien P, Dias-Freedman I, Mina M, Zimmerman M, Kaya F, Liang HP, Prideaux B, Dietzold J, Salgame P, Savic R, Linderman J, Kirschner D, Pienaar E, Dartois V. 2018. Antimicrob Agents Chemother. 2019 Feb; 63(5).

Prediction of Drug Penetration in Tuberculosis Lesions. Sarathy JP, Zuccotto F, Hsinpin H, Sandberg L, Via LE, Marriner GA, Masquelin T, Wyatt P, Ray P, Dartois V. ACS Infect Dis. 2016 Aug 12;2(8):552-63.